摘要Since the discovery of penicillin in 1928,antibiotics have revolutionized modem medicine by effectively treating infec-tious diseases and saving countless lives.However,the wide-spread development of antimicrobial resistance(AMR)now threatens the efficacy and longevity of these critical drugs.A study published in The Lancet reported that bacterial AMR contributed to approximately 4.95 million deaths globally in 2019,with 1.27 million directly attributable to AMR(Fig.1)[1].Natural products(NPs)continue to play a crucial role in discovering new antibiotics,as they can bypass the penetration barriers of target bacteria in ways that synthetic methods cannot[21.In the past two decades,traditional screen-ing methods for antimicrobial drugs have become increas-ingly ineffective,underscoring the urgent need to identify novel molecules with unique mechanisms of action.Recently,Shukla et al.published a paper in Cell,unveiling clovibactin,a new antibiotic derived from an uncultured soil bacterium.This compound has shown efficacy in killing drug-resistant Gram-positive bacteria without promoting the development of resistance[3].