摘要Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes,designated callicain-tides A-E(1-5),were isolated from Callicarpa integerrima.Compounds 1 and 2 feature a distinctive 5/6-membered ring system,while compounds 3-5 are characterized by progressively truncated carbon skeletons,containing 18,17,and 16 carbons,respectively.In addition,four known compounds 6-9 were also identified.Their structures were elucidated using advanced spectroscopic tech-niques,including nuclear magnetic resonance(NMR),high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),ultra-violet(UV),infrared radiation(IR),optical rotatory dispersion(ORD),DP4+analysis and electronic circular dichroism(ECD),sup-ported by quantum chemical calculations.Compounds 1-9 were evaluated for their anti-MRSA activity.Among them,compound 6 demonstrated significant anti-MRSA activity,with a minimum inhibitory concentration(MIC)of 16 μg·mL-1.
作者WANG Mengru[1]WANG Qi[2]MA Yanzi[3]ZEB Muhammad Aurang[1]LI Xiaoli[1]SHEN Feng[4]XIAO Weilie[3]学术成果认领
作者单位Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Characteristic Plant Extraction Laboratory,Yunnan Key Laboratory of Research and Development for Natural Products,State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,School of Pharmacy and School of Chemical Science and Technology,Yunnan Uni-versity,Kunming 650500,China[1]State Key Laboratory of Microbial Metabolism,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China[2]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Characteristic Plant Extraction Laboratory,Yunnan Key Laboratory of Research and Development for Natural Products,State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,School of Pharmacy and School of Chemical Science and Technology,Yunnan Uni-versity,Kunming 650500,China;Southwest United Graduate School,Kunming 650592,China[3]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China[4]
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