摘要Atopic dermatitis(AD)is a chronic inflammatory skin condition.Natural products have gained traction in AD treat-ment due to their accessibility,low toxicity,and favorable pharmacological properties.However,their application is primarily con-strained by poor solubility,instability,and limited permeability.The transdermal drug delivery system(TDDS)offers potential solu-tions for transdermal delivery,enhanced penetration,improved efficacy,and reduced toxicity of natural drugs,aligning with the re-quirements of modem AD treatment.This review examines the application of hydrogels,microneedles(MNs),liposomes,nanoemul-sions,and other TDDS-carrying natural products in AD treatment,with a primary focus on their effects on penetration and accumula-tion in the skin.The aim is to provide valuable insights into the treatment of AD and other dermatological conditions.