摘要The research and development of new traditional Chinese medicine(TCM)drugs have pro-gressively established a novel system founded on the integration of TCM theory,human ex-perience,and clinical trials(termed the"Three Combinations").However,considering TCM's distinctive features of"syndrome differentiation and treatment"and"multicomponent formu-lations and complex mechanisms",current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering hu-man experience data,evaluating clinical efficacy,and controlling the quality of active ingredi-ents,which impede the innovation process in TCM drug development.Network pharmaco-logy,centered on the"network targets"theory,transcends the limitations of the conventional"single target"reductionist research model.It emphasizes the comprehensive effects of dis-ease or syndrome biological networks as targets to elucidate the overall regulatory mechan-ism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a"next-generation drug research model".To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,ap-plicable pathways,and specific applications of network pharmacology as a new theory,meth-od,and tool in TCM drug development.The goal is to enhance the quality of TCM drug re-search and development and accelerate the efficiency of developing new TCM products.