摘要Arthritis,encompassing osteoarthritis(OA),rheumatoid arthritis(RA),and gouty arthritis(GA),is a prevalent inflammatory disease that significantly impacts quality of life.Natural products(NPs),derived from animals,plants,marine organisms,and microorganisms,have demonstrated beneficial effects in arthritis treatment both domestically and internationally.These natural compounds offer advantages in drug discovery due to their skeletal diversity,structural complexity,and multi-effect,multi-target,and low-toxicity properties compared to conventional small-molecule medicines.However,unclear mechanisms have hindered the de-velopment and clinical application of NPs.This review summarizes recent experimental stud-ies from the past decade on natural medicine for arthritis treatment,emphasizing key NPs with therapeutic effects on OA,RA,and GA.It examines the effects and molecular mechan-isms of NPs acting on different cells to treat arthritis.Furthermore,this review provides in-sights into the future prospects of NP research in this field,which is crucial for advancing NP-based arthritis treatments.