摘要Fibrosis is characterized as an aberrant reparative process involving the direct replacement of damaged or deceased cells with connective tissue,leading to progressive architectural remod-eling across various tissues and organs.This condition imposes a substantial burden,result-ing in considerable morbidity and mortality.Ginseng(Panax ginseng C.A.Meyer),renowned for its medicinal properties,has been incorporated as a key component in Chinese patent medicines to mitigate fibrotic diseases.Ginsenosides,the primary bioactive compounds in ginseng,have garnered significant attention.Over the past five years,extensive research has explored the pharmaceutical potential of ginsenosides in diverse organ fibrosis conditions,in-cluding liver,myocardial,renal,and pulmonary fibrosis.Studies have elucidated that ginsen-osides demonstrate potential effects on inflammatory responses stemming from paren-chymal cell damage,myofibroblast activation leading to extracellular matrix(ECM)produc-tion,and myofibroblast apoptosis or inactivation.Additionally,potential downstream targets and pathways associated with these pathological processes have been identified as being in-fluenced by ginsenosides.This review presents a comprehensive overview of the efficacious treatments utilizing ginsenosides for various tissue fibrosis types and their potential anti-fibrotic mechanisms.Furthermore,it offers a reference for the development of novel candid-ate drugs for future organ fibrosis therapies.