摘要Dysfunction of drug transporters significantly affects therapeutic outcomes and drug efficacy in patients with liver injury.Clinical and experimental evidence demonstrates that liver in-jury involves complex inter-organ interactions among the brain,eye,liver,intestine,and kid-ney.Recent advances in basic and clinical research have illuminated the physiologic and mo-lecular mechanisms underlying transporter alterations in liver injury,particularly those asso-ciated with bilirubin,reactive oxygen species,ammonia,bile acid,and inflammatory factors.Notably,the influence of these transporter modifications on drug pharmacokinetics in liver injury patients remains inadequately understood.Additional research is necessary to fully comprehend these effects and their therapeutic implications.The documented alterations of transporters in distant organs across various liver diseases indicate that dosage modifica-tions may be required when administering transporter-substrate drugs,including both tradi-tional Chinese and Western medicines,to patients with liver dysfunction.This strategy helps maintain drug concentrations within therapeutic ranges while reducing adverse reactions.Furthermore,when utilizing transporter inducers or inhibitors clinically,consideration of their long-term effects on transporters and subsequent therapeutic impact is essential.Care-ful attention must be paid to avoid compromising the elimination of toxic metabolites and proteins when inhibiting these transporters.Similarly,prudent use of inducers or inducer-type therapeutic drugs is necessary to prevent enhanced drug resistance.This review exam-ines recent clinical and experimental findings regarding the inter-organ interaction of drug transporters in liver injury conditions and their clinical relevance.