摘要Natural herbs demonstrate significant therapeutic potential in managing chronic and com-plex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug interactions.Furthermore,insufficient standardized evid-ence and global acceptance impede their widespread adoption.Liposomes,nanocarriers con-sisting of a phospholipid bilayer enclosing an aqueous core,present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds.These adapt-able systems can encapsulate both hydrophilic and hydrophobic agents,enabling targeted drug delivery and enhanced stability.Moreover,liposomes can be modified to carry diagnost-ic and imaging agents,enabling precise disease detection and monitoring.While liposomes of-fer potential as an innovative delivery technology for herbal remedies,their application in Traditional Chinese Medicine(TCM)remains relatively unexplored.TCM,with its holistic,en-ergy-based approach to health and organ function,presents distinct challenges regarding for-mulation and delivery.This review examines the therapeutic potential of herbal medicines,emphasizing how liposomes address delivery challenges within the TCM framework.It also investigates the integration of TCM with Western medical practices,demonstrating how lipo-somal systems may bridge these approaches.The review analyzes key formulation tech-niques for TCM-loaded liposomes,particularly the microfluidic method,which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods.The analysis addresses barriers to integrating liposomal delivery systems with TCM,including physicochemical properties,scalability issues,and regulatory challenges.Finally,this review provides strategic recommendations for overcoming these obstacles and identi-fies future research directions to maximize the potential of liposomal technology in enhan-cing TCM therapies.