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(±)-Talapyrones A-F:six pairs of dimeric polyketide enantiomers with unusual 6/6/6 and 6/6/6/5 ring systems from Talaromyces adpressus

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摘要(±)-Talapyrones A-F(1-6),six pairs of dimeric polyketide enantiomers featuring unusual 6/6/6 and 6/6/6/5 ring systems,were isolated from the fungus Talaromyces adpressus.Their structures were determined by spectroscopic analysis and HR-ESI-MS data,and their abso-lute configurations were elucidated using a modified Mosher's method and electronic circular dichroism(ECD)calculations.(±)-Talapyrones A-F(1-6)possess a 6/6/6 tricyclic skeleton,presumably formed through a Michael addition reaction between one molecule of α-pyrone derivative and one molecule of C8 poly-β-keto chain.In addition,compounds 2/3 and 4/5 are two pairs of C-18 epimers,respectively.Putative biosynthetic pathways of 1-6 were dis-cussed.

作者 Meijia Zheng ^[1] Xinyi Zhao ^[1] Chenxi Zhou ^[2] Hong Liao ^[1] Qin Li ^[1] Yuling Lu ^[1] Bingbing Dai ^[1] Weiguang Sun ^[1] Ying Ye ^[1] Chunmei Chen ^[1] Yonghui Zhang ^[1] Hucheng Zhu ^[1] 学术成果认领

作者单位 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China ^[1] Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China ^[2]

关键词 Polyketides Talaromyces adpressus Enantiomers Structure elucidation Biosynthetic pathways

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Original articles

DOI 10.1016/S1875-5364(25)60928-9

发布时间 2025-08-13（万方平台首次上网日期，不代表论文的发表时间）

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