摘要Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The ad-vent and implementation of advanced technologies,such as culture strategies,genomics min-ing,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical re-search,introducing innovative methodologies and perspectives.The development and matur-ation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent devel-opments in this context,emphasizing their applications in pharmaceutical discovery and de-velopment.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.