摘要目的 探讨结直肠癌组织中5-脂氧合酶(5-LOX)的表达与患者临床病理因素的关系.方法 采用免疫组化SP法检测52例结直肠癌患者肿瘤组织中5-LOX的表达,分析5-LOX与结直肠癌患者临床病理因素的关系.结果 52例结直肠癌标本中,5-LOX表达阳性者38例(73.1％).5-LOX阳性表达率淋巴结转移组[87.8％(36/41)]高于无转移组[18.2％(2/11),P＜0.05],浸润较深组[T3～T4,81.1％(30/37)]高于浸润较浅组[T1～T2,53.3％(8/15),P＜0.05]；Ⅲ、Ⅳ期组[79.5％(31/39)]高于Ⅰ、Ⅱ期组[53.8％(7/13),P＜0.05]；低分化和未分化组[100％(24/24)]高于高、中分化组[50.0％(14/28),P＜0.05]；而肿瘤大小、脉管侵犯、腹膜转移与5-LOX阳性表达率无关.结论 5-LOX在结直肠癌组织中的阳性表达与肿瘤淋巴转移、浸润深度、分化程度和TNM分期有关.

abstractsObjective To examine the association of 5-lipoxygenase (5-LOX) expression with clinicopathological factors in colorectal cancer.Methods Immunohistochemical stain was used to detect the 5-LOX expression in 52 resected specimens of colorectal cancer.The association between 5-LOX expression and clinicopathological factors was examined.Results The positive rate of 5-LOX expression in 52 specimens of colorectal carcinoma was 73.1％ (38/52).In 41 colorectal cancer specimens with lymph node metastasis,the positive rate of 5-LOX expression was higher than that in the specimens without metastasis(87.8％ vs.18.2％,P＜0.05).The positive rate of 5-LOX expression in the specimens with deep infiltration (T3 and T4) was higher than that in the specimens with superficial infiltration(T1 and T2)(81.1％ vs.53.3％,P＜0.05).The positive rate of 5-LOX expression in TNM stage Ⅲ and Ⅳ cancer was higher than that in stage Ⅰ and Ⅱ (79.5％ vs.53.8％,P＜0.05).The positive rate of 5-LOX expression in cancers of poor differentiation and non-differentiation adenocarcinoma was higher than that of well and moderately differentiated cancer (100％ vs.50.0％,P＜0.05).There were no significant differences of 5-LOX expression with tumor size,vascular invasion and peritoneal dissemination.Conclusion 5-LOX expression in colorectal carcinoma is closely associated with lymph node metastasis,infiltration depth,differentiation degree and TNM stage.