摘要目的:评价盆腔恶性肿瘤层面优先入路全盆腔脏器切除术的可行性及安全性，并探索影响患者无复发生存（RFS）因素。方法:本研究采用描述性病例系列研究方法。回顾性收集2017年9月至2025年3月期间，于天津市人民医院接受层面优先入路全盆腔脏器切除术患者临床资料。层面优先入路全盆腔脏器切除手术操作遵循“先间隙后血管神经”的原则，即优先分离全盆腔脏器周围的无血管间隙，在充分游离并离断相关血管和神经后，再切断远端或经会阴途径将脏器整块切除。本研究观察指标包括手术情况、术后病理指标及并发症发生情况（根据Clavien-Dindo标准进行术后并发症分级）；无复发生存期（RFS）和总生存期（OS）、肿瘤特异生存期（TSS）；影响本组患者RFS的因素。结果:共纳入41例患者，其中原发肿瘤30例（73.2%），复发肿瘤11例（26.8%）。开腹全盆腔脏器切除5例（12.2%），腹腔镜全盆腔脏器切除36例（87.8%），手术均采用层面优先入路并顺利完成，无围手术期死亡发生。34例（82.9%）R 0切除，7例（17.1%）R 1切除，中位手术时间500（265~740）min，中位术中出血量200（10~3 500）ml。共有12例（29.3%）发生术后并发症，Clavien-Dindo Ⅲ级并发症2例，其中1例患者术后29 d因盆腔血肿行腹腔镜探查，术中未见活动性出血，术后再次出血，行介入造影提示髂内动脉主干假性动脉瘤，经髂内动脉介入栓塞治疗痊愈；另1例患者行保留膀胱的全盆腔脏器切除术后5 d发生尿瘘，改行腹腔镜下膀胱切除及双侧输尿管皮肤造口术。中位随访18（1~90）个月，本组患者的5年RFS及OS分别为46.7%和52.2%，5年TSS为67.8%。单因素Cox回归分析显示，切缘阳性（ P<0.001）、侧盆壁侵犯（ P=0.014）、脉管侵犯（ P=0.004）是本组患者RFS的影响因素；多因素分析显示，切缘阳性（HR：21.93，95%CI：3.78~127.42， P<0.001）是本组患者RFS的独立影响因素。 结论:盆腔恶性肿瘤患者行层面优先入路全盆腔脏器切除手术安全可行，切缘阳性是影响该类患者RFS的关键因素。

abstractsObjective:To evaluate the feasibility and safety of a fascial space priority approach to total pelvic exenteration (TPE) in patients with pelvic malignancy.Methods:This was a descriptive case series. Relevant clinical data of patients who had undergone TPE via a fascial space priority approach at Tianjin Union Medical Center from September 2017 to March 2025 were retrospectively collected. All operations had been performed via a fascial space priority approach, the guiding principle of which is separating the avascular pelvic spaces first and then transecting the vessels and nerves of the pelvic organs. That is, the avascular planes around all the pelvic organs are dissected first, after which the relevant vessels and nerves are fully dissected and transected, followed by en bloc resection of pelvic organs distally or via perineal approach. The variables studied included relevant surgical parameters, postoperative pathological findings, complications (classified according to the Clavien-Dindo criteria); recurrence-free survival (RFS), overall survival, and tumor-specific survival. Results:The study cohort comprised 41 patients, including 30 (73.2%) with primary tumors and 11 (26.8%) with recurrent tumors. Open TPE was performed on five patients (12.2%) and laparoscopic TPE on the remaining 36 (87.8%). All procedures were successfully completed with a fascial space priority approach and there were no intraoperative deaths. R0 resection was achieved in 34 patients (82.9%) and R1 resection in seven (17.1%). The operation time was 500 (265-740) min, and the amount of bleeding 200 (10-3,500) mL. Twelve patients (29.3%) developed postoperative complications, two of which were Clavien-Dindo Grade III complications. One of these patients required re-operation to manage a pelvic hematoma 29 days after the primary TPE. No active bleeding was observed during the re-operation. Another patient underwent interventional angiography for an episode of postoperative bleeding; this showed a pseudoaneurysm of the internal iliac artery that was successfully treated by interventional embolization via the internal iliac artery. Five days after undergoing a primary TPE with bladder preservation, a third patient was found to have a urinary fistula and underwent laparoscopic bladder resection with percutaneous ureterostomy. The median duration of follow-up was 18 (1-90) months. The 5-year RFS and overall survival were 46.7% and 52.2%, respectively, whereas the 5-year tumor-specific survival was 67.8%. Univariate Cox regression analysis identified a positive surgical margin ( P < 0.001), lateral pelvic sidewall invasion ( P=0.014), and vascular invasion ( P=0.004) as significantly associated with RFS, whereas multivariate analysis identified only a positive surgical margin (HR: 21.93, 95% CI: 3.78-127.42, P<0.001) as an independent predictor of RFS. Conclusions:It is safe and feasible to perform TPE with a fascial space priority approach on patients with pelvic malignancy. Positive surgical margins are significantly associated with RFS.