胃食管反流病欧洲微创外科的规范与创新实践
Strategies and innovative practices of European minimally invasive surgery for gastroesophageal reflux disease
摘要胃食管反流病(GERD)为全球常见食管疾病,可进展为糜烂性食管炎、Barrett食管甚至食管腺癌。长期应用质子泵抑制剂无法从根本上纠正抗反流屏障功能缺陷,且约40%患者症状控制不佳。探索个体化、规范化及创新的抗反流手术策略,有助于提升治疗效果与改善患者预后。本文基于现有文献与欧洲临床实践经验,总结了GERD的关键生理基础,梳理了经典抗反流手术方式以及包括磁性括约肌增强术(LINX?)和RefluxStop?硅胶植入物在内的创新性食管下括约肌(LES)增强手段。在手术策略层面,食管裂孔修补与LES增强仍是抗反流手术的核心要素;经典胃底折叠术依然可靠,但其机械性改变带来部分患者不适;LINX?与RefluxStop?具有微创、可逆等优势,在控制反流的同时可降低相关不良事件风险。新型植入技术有望逐步替代传统折叠术,手术选择应遵循医患共同决策,实现个体化精准治疗。
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abstractsGastroesophageal reflux disease (GERD) is a common esophageal disorder worldwide and can progress to erosive esophagitis, Barrett's esophagus, and even esophageal adenocarcinoma. Long-term use of proton pump inhibitors cannot fundamentally correct the functional impairment of the anti-reflux barrier, and symptom control is inadequate in approximately 40% of patients. Exploring individualized, standardized, and innovative anti-reflux surgical strategies is conducive to enhancing therapeutic efficacy and improving patient prognosis. Based on existing literature and European clinical practice experience, this article summarizes the key physiological basis of GERD, outlines classic anti-reflux surgical procedures, and reviews innovative lower esophageal sphincter (LES) augmentation techniques, including magnetic sphincter augmentation (LINX?) and the RefluxStop? silicone implant. Regarding surgical strategy, hiatal hernia repair and LES augmentation remain core elements of anti-reflux surgery. Classic fundoplication remains reliable; however, its mechanical alteration can cause discomfort in some patients. LINX? and RefluxStop? offer advantages such as minimally invasive application and reversibility, effectively controlling reflux while reducing the risk of related adverse events. These novel implant technologies may progressively replace traditional fundoplication. Surgical intervention should adhere to the principle of shared decision-making to achieve individualized and precise treatment.
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