摘要长链非编码RNA(lncRNA)作用机制多样,在多层面可调控基因的表达水平,与肿瘤形成、病毒复制、炎症损伤等病理过程紧密相关.lncRNA的异常表达参与疾病的病理生理改变,在mRNA的稳定、翻译水平调节、蛋白运输、RNA加工和修饰等诸多环节发挥关键作用.脓毒症炎症损伤的发生发展是一个涉及多基因、多通路的复杂过程,存在众多编码或非编码基因的结构和表达异常.综述lncRNA在调控线粒体分裂、调控促炎因子、调控钙离子转运、调控核转录因子-κB(NF-κB)信号通路及调控其他炎症损伤等方面的研究进展,为脓毒症的诊治提供新的手段.

abstractsThe mechanism of long chain non-coding RNA (lncRNA) is diverse. LncRNA can regulate the expression of genes at multiple levels and is closely related to some pathological process, such as tumor formation, viral replication, inflammatory damage, etc. The abnormal expression of lncRNA is involved in the patho-physiological changes of the disease, and plays a key role in many links, such as the stability of mRNA, the regulation of translation level, protein transport, RNA processing and modification, and so on. The development of sepsis inflammatory injury is a complex process involving multiple genes and pathways, in which the abnormal structure and expression of many encoding genes or non-coding genes exist.This paper review the research progress on lncRNA in the regulation of chondriokinesis, pro-inflammatory cytokines, calcium ion transport, nuclear factor-κB (NF-κB) in signal pathway and other inflammatory lesions, which may provide a new method for the diagnosis and treatment of sepsis.