摘要皮离蛋白(DCD)最早是在人体皮肤汗腺中分离发现的,具有抗微生物作用,被定义为一种新的小分子抗微生物肽,是人类皮肤汗腺中作为先天免疫防御系统的一部分.随着对DCD的研究进展,其广泛的生物学功能逐渐被发现.2010年以来,多项研究表明DCD可能是一种新的动脉硬化的危险因素,其在缺血性心脏病中的作用逐渐引起关注,特别是它与胰岛素分泌和血糖控制的关系、与一氧化氮(NO)合成和高血压的关系、与诱导血小板聚集以及诱发急性心肌梗死(AMI)的关系等逐渐得到实验证实,同时还证实了阿司匹林对DCD的多种生物学功能具有对抗和逆转作用.对DCD在心脑血管疾病中作用的深入研究可能为心脑血管事件的预防、预警、预后评价以及治疗带来突破.

abstractsDermcidin (DCD) was found in isolated human skin sweat glands with antimicrobial effect, and was defined as a kind of new small molecule antimicrobial peptide. It was a part of human sweat glands in the skin as the immune system's innate defense. With the studies of DCD, its extensive biological functions are gradually discovered. Since 2010, a number of studies have shown that DCD may be a new risk factor for atherosclerosis. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis and hypertension, platelet aggregation and acute myocardial infarction (AMI). In those experiments, it was also confirmed that aspirin had antagonistic and reverse effects on various biological functions of DCD. Further research on the role of DCD in cardiovascular and cerebrovascular diseases may lead to the prevention, early warning, prognosis evaluation and treatment breakthrough of cardiovascular and cerebrovascular events.