摘要目的 建立脑力疲劳研究的实验室模型,探讨和评估持续认知操作任务前后注意测验和P300的变化.方法 20名青年男性受试做自身前后对照,持续完成8h的认知操作任务,在任务前后分别完成注意测验和事件相关电位(ERP)的测量,并对被试的主观疲劳感做出评价.结果 脑力疲劳前后注意测验成绩差异有显著性,黑红数字表法疲劳前后平均完成测验时间分别为(130.6±20.6)s和(142.4±24.6)s(P <0.05);注意分配检查法疲劳前后注意分配量的平均值分别为(0.86±0.06)和(0.79±0.05)(P <0.05).P300潜伏期前后比较差异无显著性,脑力疲劳后波幅明显减小,Fz点疲劳前后平均波幅分别为(7.8±5.1)μV和(5.4±5.6)μV(P <0.05).结论 事件相关电位P300的波幅差值能够为持续认知操作任务诱发脑力疲劳评估提供神经电生理证据.

abstractsObjective To establish the laboratory research model of mental fatigue,as well as to discuss and assess the changes of attention test and P300 before and after mental fatigue. Methods 20 young male students continued to complete 8h cognitive performance tasks. Auditory P300 component (evoked by oddball paradigm), attention test and the self-rating scale for subjective fatigue symptoms were recorded before and after tasks.Results Before and after mental fatigue,there was significant difference of attention test.In black-red number table test,the average time used for test completion before and after mental fatigue were respectively (130.6±20.6)s and (142.4±24.6)s,P <0.05.In attention diversion check,the average attention assignment before and after mental fatigue were respectively 0.86±0.06 and 0.79±0.05(P <0.05).There was no significant difference of P300 latency change, but there was significant difference of P300 amplitude change. The average amplitudes on Fz before and after mental fatigue were respectively (7.8±5.1)μV and (5.4±5.6)μV(P <0.05).Conclusion The amplitude change of P300 provides neuro-electrophysiological evidence for diagnosing mental fatigue.