摘要目的 探讨轻度认知功能障碍(Mild Cognitive Impairment,MCI)患者血浆蛋白磷酸酯酶-2A(protein phosphotase-2A,PP-2A)的表达.方法 用免疫印迹法检测30例不同病程MCI患者及11名正常老年人对照组血浆PP-2A的表达.结果 1年MCI组及2年MCI组血浆PP-2A的表达(0.96±0.06),(0.93±0.07)与对照组(1.00±0.08)比较差异无显著性(P>0.05),而3年MCI组的PP-2A表达(0.86±0.06)与对照组相比明显降低,差异有显著性(P<0.05),与1年MCI组比较差异有显著性(P<0.05),与2年MCI比较差异无显著性(P>0.05).结论 病程长的MCI患者血浆PP-2A的表达降低,对MCI的诊断可能有参考价值.

abstractsObjective To explore the expression of protein phosphotase-2A(PP-2A) in plasma in the patients with mild cognitive impairment. Methods The expression of PP-2A was measured by Western-blot in control group(n=11),1-year MCI group(n=10),2-year MCI group(n=10) and 3-year MCI group(n=10). Results The expression of PP-2A in 1-year MCI group(0.96±0.06) and in 2-year MCI group(0.93±0.07) was not obviously lower as compared with control group(1.00±0.08)(P>0.05),but a significant difference was induced between 3-year MCI group and control group(P<0.05),and between 3-year MCI group and 1-year MCI group(P<0.05),but wasn't between 3-year MCI group and 2-year MCI group(P>0.05). Conclusion Lower expression of PP-2A in plasma implies a possible value of MCI diagnosis.