摘要目的 探讨未有效持续稳定降压治疗的中年原发性高血压病患者认知功能的改变.方法 入组34例40～60岁中年高血压患者,病程1年以上,平时均未经过持续、有效、稳定降压治疗,采用一对一配对原则,正常对照组34例,年龄、性别和受教育年限均和高血压组匹配.认知功能测查应用认知功能成套测验-共识版,该神经心理测验包括10项分测验:连线(TMT)、符号编码(SC)、言语学习(HVLT-R)、空间广度(SS)、数字序列(DS)、迷宫(MAZES)、视觉记忆(BVMT-R)、语义流畅性(CF)、情绪管理能力(ME)和持续操作测验(CPT-IP).结果 认知功能测查分测验中的连线分数、言语流畅性和情绪管理得分高血压组[(47.81±10.85)分;(48.04±9.42)分;(47.36±10.39)分]低于对照组[(54.79±13.75)分;(53.22±12.1)分;(52.1±9.01)分],2组之间差异有显著性(t=2.19,P=0.03;t=2.03,P=0.04;t=1.98,P=0.04),其他分测验及MCCB总分2组之间差异无显著性(均P>0.05).结论 未规范治疗的中年原发性高血压病患者存在不同程度的认知功能损害.

abstractsObjective To explore change of cognitive function in middle-aged patients with primary hy-pertension receiving no effective ,persistent and steady decreasing blood pressure treatment. Methods Thirty-four patients with hypertension from 40 to 60 years old, with course of disease of more than one year,who hardly re-ceived effective,persistent and steady decreasing blood pressure treatment, were enrolled ,while 34 normal control population,matched with hypertension group in age, gender and educational duration, were recruited. The MAT-RICS Consensus Cognitive Battery (MCCB) ,as a neuropsychological test used for measuring the subjects' cogni-tive function, included, Trail Making Test (TMT), BACS-Symbol Coding Test(SC), HVLT-R-Verbal Learning(HV-LT-R), WMS-III-Spatial Span(SS) , BACS-Digit Sequencing (DS), NAB-Mazes (MAZES), BVMT-R-Visuospatial Memory (BVMT-R), BACS-Category Fluency-Animal Naming (CF), MSCEIT-Managing Emotions (ME) and Con-tinuous Performing Test-Identical Pairs(CPT-IP). Results There was significant difference in TMT and CF and ME scores between hypertension group(47.81±10.85 ;48.04±9.42 ;47.36±10.39) and control group(54.79 ±13.75;53.22±12.1 ;52.1±9.01) (t=2.19, P=0.03;t=2.03, P=0.04;t=1.98, P=0.04) ,and no signif-icant difference in other subtests scores and MCCB composite score between hypertension group and control group (P>0.05). Conclusion The different extents of damage of cognitive function may appear in middle-aged pa-tients with primary hypertension receiving no specified treatment.