摘要目的 探讨单相和双相抑郁发作患者脑血流灌注的特征及其与认知功能的相关性.方法 单相抑郁(UPD)及双相抑郁发作(BPD)患者各22人,对照组为健康志愿者15人,行单光子发射型计算机断层扫描(SPECT)检查,利用韦克斯勒成人智力测验修订版(WAIS-RC)和韦克斯勒成人记忆测验(WMA)评估受试者的认知功能,使用SPSS软件进行统计分析.结果 与正常组比较,UPD、BPD均存在双侧颞叶、额叶、海马血流低灌注(P＜0.05),BPD基底节血流灌注较UPD增高(0,22.73%;4.54%,36.36%)(P＜0.05);单、双相抑郁组间认知功能差异无统计学意义(P＞0.05);单、双相抑郁患者认知功能的降低与脑局部血流量降低有关(P＜0.05).结论 单、双相患者脑血流之间存在着差异;BPD基底节脑血流灌注较UPD增高(P＜0.05),推测基底节血流灌注增高是双相抑郁转向躁狂相的解剖基础.

abstractsObjective To analyze the correlation of cerebral perfusion characteristics and cognitive function on patients with unipolar and bipolar depression. Methods The r-CBF imaging was detected by SPECT forall subjects. Evaluated cognitive function of subjects using WAIS-CR and WMA, and analysed data using SPSS.Results Data showed that some regions in the brain, e.g. temporal lobe, frontal lobe, hippocampus, and basal ganglia, had significant alterations of r-CBF in depressed patients as compared with healthy controls (P ＜ 0. 05 ).Compared with UPD, BPD showed increased perfusion in basal ganglia ( 0,22.73%; 4.54%, 36. 36% ) (P ＜0.05 ). Furthermore there was no significant different incognitive deficits between UPD and BPD(P ＞ 0. 05 ) , and correlations between cognitive impairment and hypoperfusion of rCBF (P ＜ 0. 05 ). Conclusion There be exist difference in r-CBF between UPD and BPD. The perfusion of r-CBF in BPD is significantly increased than that in UPD,and it suggest that hyperperfusion in basal ganglia may be the biological basis when bipolar depression turning to manic.