摘要目的 探讨眼动训练对轻度认知功能障碍老人视觉注意事件相关电位(ERP)的影响.方法 将48名轻度认知障碍老人分别进行眼动训练、手指操训练和空白处理3个月,利用事件相关电位技术(e-vent-related potentials,ERPs)对训练后老人进行检测,分析比较靶刺激P3b和新异刺激P3a的波幅和潜伏期.结果 训练后,新异刺激早成分P1波幅组别主效应显著(P＜0.05),眼动训练组[(6.78±1.55)μV]和手指操训练组[(5.43±1.47)μV]较空白对照组[(3.09±0.98)μV]波幅增大,主要表现在额区.靶刺激早成分P1波幅组别主效应显著(P＜0.05),眼动训练组[(6.75±2.01)μV]高于手指操训练组[(4.12±1.33)μV]和空白对照组[(3.45±1.01)μV].P3a波幅组别主效应显著(P＜0.05),眼动训练组P3a波幅[(10.19±3.09)μV]较手指操训练组[(7.57±2.66)μV]和空白对照组[(6.06±2.03)μV]增大(P＜0.05,P＜0.05),主要表现在额区.P3a潜伏期组别主效应显著(P＜0.05),眼动训练组P3a潜伏期[(390.67±55.03)ms]较手指操训练组[(428.55±48.68)ms]和空白对照组[(435.89±59.21)ms]提前,主要表现在额区和中央顶区.结论 眼动训练可以提高MCI患者的非选择性注意力,手指操训练对视觉注意力的影响不显著.

abstractsObjective To study the visual attention of mild cognitive impairment patients (MCI)by eyes movement training. Meathods 48 mild cognitive impairment patients were divided into eye movement training group,finger training group and untreated control group by single-blind randomized block method. Then they were trained respectively three months. Event-related potentials (ERPs) were used to measure the face recognition of them before and after training. The amplitude and latency of P3b elicited by target stimuli and P3a elicited by new stimuli of the three said groups were compared and contrasted. Results After training,the amplitude of P1 elicted by novelty stimulus were larger in eye movement training group( (6.78 ± 1.55 ) μV) and in finger training group ( ( 5.43 ± 1.47 ) μV) than untreated control group ( ( 3.09 ± 0.98 ) μV) significantly, especially in the frontal area. The amplitude of P1 elicted by target stimulus were larger in eye movement training group( (6.75 ±2.01 ) μV)than in finger training group( (4.12 ± 1.33 )μV)and untreated control group( (3.45 ± 1.01 )μV)significantly, especially in the frontal area. The amplitude of P3a were larger in eye movement training group( ( 10. 19 ± 3.09)μV ) than in finger training group ( ( 7.57 ± 2.66 ) μV ) and untreated control group ( ( 6.06 ± 2.03 ) μV ) (P ＜ 0.05,P＜0.05) significantly,especially in the frontal area. The latency of P3a were earlier in eye movement training group( (390.67 ±55.03 ) ms) compared to finger training group( (428.55 ± 48.68 ) ms) and untreated control group( (435.89 ± 59.21 )ms)significantly, especially in the frontal region and central parietal area. Conclusion Eyes movement can improve the MCI patients' non-selective attention function, especially in frontal area.The finger execrises have no significant effect on visual attention.