摘要目的 采用基于体素形态学测量(VBM)和行为学相结合的方法,检测全脑容积及情绪记忆成绩,以探讨情绪记忆增强效应相关脑区形态学特点.方法 32名健康年轻人参加实验.试验过程包括情绪记忆行为学检测和磁共振扫描两个阶段,其中行为学检测包括记忆编码和再认,并记录行为学成绩.利用3.0T磁共振采集伞脑容积数据.采用VBM5对全脑容积进行分割,获得脑灰质、脑白质和脑脊液容积.运用SPM5和SPSS13.0统计软件包进行相关统计分析.结果 情绪图片再认正确率较中性图片正确率高(t=5.08,P＜0.01),增强效应明显(△Pr=0.12±0.01)；情绪记忆增强效应主要相关脑区包括双侧杏仁核、额叶背外侧、额中回、前额叶背内侧、梭状回、右侧海马旁回、左侧眶回、中扣带回,并与双侧杏仁核容积率显著相关(左:r=0.564,P＜0.01,右:r=0.541,P＜0.01).结论 从脑形态结构水平证实了杏仁核等相关脑区是参与情绪记忆的重要脑结构,进一步扩展了功能成像的相关研究结果.

abstractsObjective The brain volume and behavioral performance of emotional memory were measured by combining voxel-hased morphometry (VBM) and behavior to explore the morphological characters of brain regions related to the emotional enhancement effect of memory.Methods A total of 32 healthy young subjects participated in the study.The experimental processes included MR scan and behavioral performance of emotional memory the latter of which involved two phases-encoding and retrieval.Behavioral performance was recorded and the whole-brain 3D MRI data were acquired via 3.0T MR.3D MRI data were segmented by VBM5,and the wholebrain volumes of gray matter,white matter and CSF were produced.SPM5 and SPSS13.0 were used for statistical analysis of the 3D MRI data and behavioral data,respectively.Results Retrieval accuracy of the emotional pictures was higher than that of the neutral pictures ( t =5.08,P＜0.001 ),the emotional enhancement effect was significant ( Δ Pr =0.12 ± 0.01 ).Brain regions related to emotional enhancement effect included bilateral amygdala,dorsolateral prefrontal cortex,middle frontal gyrus,dorsomedial prefrontal cortex,fusiform gyms,right parahippocampus,left orbitofrontal cortex and middle cingulate gyms.Volume ratio of bilateral amygdala were related to emotion enhancement effect evidently (left:r=0.564,P＜0.01 ; right:r=0.541,P＜0.01 ).Conclusion This study morphologically confirms that brain regions,such as amygdale and prefrontal cortex,are critical structures for the enhancement of emotional memory,and further extends the findings of previous functional imaging studies.