摘要目的 通过Go/Nogo任务的行为学和事件相关电位,研究注意缺陷多动障碍(ADHD)儿童脑电生物反馈治疗前后的变化,探讨脑电生物反馈治疗ADHD的疗效.方法 选择42例ADHD儿童进行脑电生物反馈治疗20次,治疗前后分别完成Go/Nogo任务,同时记录行为学和脑电数据,对治疗前后的行为学和事件相关电位进行比较分析.结果 ①行为学:ADHD脑电生物反馈治疗后的虚报错误数[(2.95±2.22)个]明显低于治疗前[(4.65±4.47)个],差异有统计学意义(P＜0.05).②事件相关电位:脑电生物反馈治疗后,ADHD儿童Go刺激的P2波潜伏期[(210.00±27.54) ms]和N2波潜伏期[(310.59±45.82) ms]明显短于治疗前[(228.27±34.17) ms,(328.00±42.27)ms],差异有统计学意义(P＜0.05)；Nogo刺激的N2波幅治疗后[(0.23±3.79)μV]明显低于治疗前[(-1.84±4.23)μV],差异有统计学意义(P＜0.05).结论 脑电生物反馈治疗可以减少ADHD儿童多动冲动行为,提高对靶刺激的察觉能力,改善注意力和冲突监测能力.脑电生物反馈是一种治疗ADHD的有效方法.

abstractsObjective To examine the curative effect of EEG biofeedback therapy on children with attention deficit hyperactivity disorder (ADHD),and to investigate the neural mechanism underlying the executive function in children with ADHD.Methods 42 children with ADHD participated a Go/Nogo task before and after the EEG biofeedback therapy which was consisted of 20 times of treatments.The curative effect was evaluated using the behavioral and electrophysiological indexes associated with the Go/Nogo processing in the experiment.Results Commission error significantly decreased after the therapy ( (2.95 ±2.22 ) vs (4.65 ±4.47),P＜0.05 ).Latencies of P2 ( (210.00 ± 27.54) ms vs ( 228.27 ± 34.17 ) ms) and N2 components ( ( 310.59 ± 45.82) ms vs (328.00 ± 42.27)ms) elicited by Go trials significantly exhibited shorter at the end of therapy.Additionally,the amplitude of N2 component elicited by Nogo trials exhibited significantly decreased after therapy ((0.23 ±3.79)μV vs (-1.84 ± 4.23 ) μV,P ＜ 0.05).Conclusion The EEG biofeedback therapy is effective in debasing the hyperactivity/impulsive behaviors and improving the ability of target detection,which may be beneficial to the attention ability and conflict detecting in children with ADHD.EEG biofeedback is an effective treatment to ADHD.