摘要目的 探讨壳聚糖卵磷脂对轻度认知障碍(MCI)患者语义理解N400的影响.方法 从潍坊某老年院500名老年人中用简易智能状态量表检查(MMSE)筛选出了32名MCI患者,按照随机数字表分为观察组(n=16)和对照组(n=16),观察组给予壳聚糖卵磷脂,对照组给予等剂量的安慰剂,干预时间为2个月,干预前后应用语义违例实验要求被试者进行语义判定,同时记录32名MCI患者干预前后的脑电图并分析数据.结果 1)2组均产生较明显的额、中央、顶区分布的特异性成分N400；2)观察组反应时及正确率[分别为(965.13±178.07)ms,(92.56±2.36)％],对照组反应时间及正确率[分别为(1126.13±252.77)ms,(85.28±5.73)％],差异有统计学意义(P＜0.05)；3)观察组N400潜伏期为[(425.28±47.26)ms],缩短于对照组[(456.19±37.75) ms],差异有统计学意义(F=6.01,P＜ 0.05)；观察组N400波幅为[ (4.79 ±2.18) μV],高于对照组[(3.59±1.33)μV],差异有统计学意义(F=5.96,P＜0.05).结论 壳聚糖卵磷脂能够使MCI患者的N400潜伏期缩短,波幅增高,对MCI患者语义理解的恢复有一定的帮助.

abstractsObjective To study the impact of Chitosan Lecithin on the mild cognitive impairment(MCI) patients' semantic understanding by event-related potential N400.Methods 32 patients with MCI were screened from 500 elder people aged Court in Weifang by mini-mental state examination (MMSE) scale,and were divided into two groups:the observation group ( n=16) and the control group ( n=16) by the table of random numbers.The observation group were given Chitosan Lecithin while the control group were given an equal dose of placebo.The intervention time was 2 months.The subjects were asked to conduct semantic judgement by semantic violation experiment.Thirty-two channels electroencephalogram(EEG) was recorded by Neuroacan Nuamps Systerm and analyzed data.Results 1 ) Specific component N400 was found in both groups,which was distributed at the frontal,central and parietal regions.2 ) The observation group reaction time and correct rate were respectively (965.13 ± 178.07 ) ms and ( 92.56 ± 2.36 ) ％ ,while the control group were respectively ( 1126.13 ± 252.77 ) ms and (85.28 ± 5.73 )％,with significant difference(P ＜ 0.05 ).3 ) Compared with N400 in control group,N400 latency was shorter ( (425.28 ±47.26) ms vs (456.19 ± 37.75 ) ms,F=6.01,P＜0.05) and amplitude was higher ( (4.79 ±2.18)μV vs (3.59 ± 1.33) pV,F=5.96,P＜0.05).Conclusion Chitosan lecithin has the effect of N400 latency and amplitude,it may be helpful for the patients of MCI in semantic understanding.