摘要目的 运用静息功能磁共振(rs-fMRI)比率低频振幅(fALFF)方法探讨大脑自发活动强度与Go/Nogo任务表现是否存在相关性,探索反应抑制的功能机制.方法 本院实习大学生24名,采集其静息功能磁共振BOLD信号及Go/Nogo任务行为表现,计算fALFF值和个体内变异系数,进行皮尔森相关分析获取显著性相关脑区图(校正后,P＜0.05).结果 fALFF与个体内变异系数显著负相关脑区:右直回(BA11,r=-0.66),右额上回(BA10,r=-0.82),左额中回(BA10,r=-0.80),左额下回(BA45,r=-0.78),右顶下小叶(BA2,r=-0.78),左辅助运动区(BA6,r=-0.70),右侧小脑(r=-0.63).fALFF与个体内变异系数显著正相关脑区:双侧楔叶(BA18/19,r=0.68),左枕中回(BA19,r=0.73),左枕下回(BA19,r=0.76),双侧舌回(BA17,r=0.77).结论 静息态大脑前额叶、辅助运动区、后部枕叶、小脑及部分默认网络区域的自发活动强度与Go/Nogo任务表现有显著相关性.

abstractsObjective To investigate the correlation of spontaneous brain activity and Go/Nogo task performance with fractional amplitude of low-frequency fluctuation (fALFF)of the resting-state fMRI,and explore the functional basis of response inhibition.Methods Twenty-four college students were experienced resting-sate fMRI scans and Go/Nogo task and blood oxygenation level dependent (BOLD) signal and task behavioral performance were acquired to calculate the fractional amplitude of low-frequency fluctuation (fALFF)and intra-individual coefficient of variation(ICV).Pearson's correlation analysis between the fALFF values and the ICV was performed in a voxel-wise manner to get the significant fALFF-ICV correlation map(corrected,P ＜ 0.05).Results Significant negative fALFF-ICV correlations were observed in right gyrus rectus(BA11,r =-0.66),right superior frontal gyrus(BA10,r =-0.82),left mediate frontal(BA10,r =-0.80),left inferior frontal gyrus (BA45,r =-0.78),right inferior parietal lobule(BA2,r =-0.78),left supplementary motor area(BA6,r =-0.70) and right cerebellum(r=-0.63).Significant positive fALFF-ICV correlations were observed in bilateral cuneus gyrus(BA18/19,r =0.68),left middle occipital cortex (BA19,r =0.73),left inferior occipital cortex (BA19,r =0.76) and bilateral lingual gyrus(BA17,r=0.77).Conclusion Close correlations between resting-state brain activities and Go/Nogo task performance are observed in the frontal cortex,supplementary motor area,posterior occipital lobe,cerebellum and some DMN regions.It is indicated that prefrontal cortex may have important influence on the efficiency of response inhibition,meanwhile,the default mode network may have possible influence on the efficiency of task performance.