摘要目的 分析正常健康者不确定奖赏抉择加工过程的激活脑区情况.方法 15名正常健康者进行3种不同程度(确定、风险、含糊)奖赏抉择实验,通过GE3.0T磁共振与脑功能视听觉刺激系统对受试者进行大脑同步扫描.采用SPM8分析获得相关激活脑区和激活强度值.结果 确定奖赏抉择时眶额叶被激活,平均激活强度2.4328 ±0.1949(P＜ 0.05)；风险奖赏抉择时前额叶、中央前回、枕叶联合视皮层、顶下小叶、小脑后叶、颞中回、颞下回、边缘叶及中脑被激活,平均激活强度2.4228±1.3762 (P＜ 0.05)；含糊奖赏抉择时前额叶、颞极区及颞下回、枕叶视皮层、小脑后叶被激活,平均激活强度2.4056±0.4222(P＜0.05).风险奖赏抉择与确定奖赏抉择比较,腹外侧前额叶、前额叶额极、眶额叶、中央前回、颞下回及梭状回、缘上回、顶下小叶、小脑后叶显著被激活(P＜0.05)；含糊奖赏抉择与确定奖赏抉择比较,前额叶额极显著被激活(P＜0.05)；与风险奖赏抉择比较,背外侧前额叶、小脑后叶显著被激活(P＜0.05).结论 不确定性奖赏程度不同,参与加工的脑区存在显著差异.

abstractsObjective To research the activated brain areas of decision making under uncertainty reward processing on healthy volunteers.Method The E-Prime programs were presented 3 kinds of tasks of the decision under uncertain reward processing.15 right-handed healthy volunteers made a response after receiving the task.At the same time,the GE 3.0T magnetic resonance scanner scanned the brains areas of subjects.Individual analysis and group analysis was done with SPM8 software,then the brain activating regions and the peak intensity were gotten.Results Orbitofrontal cortex was activated in certainty,peak intensity 2.4328 ± 0.1949 (P ＜ 0.05).Prefrontal cortex,occipital lobe,parietal lobe,posterior lobe of cerebellum,limbic lobe and midbrain were activated under the risk reward processing,peak intensity 2.4228 ± 1.3762 (P ＜ 0.05).When under ambiguity reward processing,prefrontal cortex,temporal lobe,occipital lobe,left inferior frontal gyrus and posterior lobe of cerebellum were activated,peak intensity 2.4056 ± 0.4222 (P ＜ 0.05).Compared with the task under certainty,posterior lobe of cerebellum,gyri subtemporalis and gyri fusiformis,inferior parietal lobule,anterior central convolution,orbitofrontal cortex,ventrolateral prefrontal cortex,both frontopolar and supramarginal gyrus were activated in task under risk (P ＜0.05) ;and both frontopolar were activated in task under ambiguity (P ＜ 0.05).Compared with the task under risk,dorsolateral prefrontal cortex and posterior lobe of cerebellum were activated in task under ambiguity (P ＜ 0.05).Conclusion There are differences in different types of reward processing of decision making.