摘要目的 探讨色氨酸羟化酶2 (THP2) rs4570625和rs4565946位点单核苷酸多态性在卒中后焦虑(poststroke anxiety disorders,PSA)发病机制中的作用.方法 通过汉密尔顿焦虑量表(HAMA)将急性缺血性脑卒中患者为PSA组(112人)和对照组(246人),采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术分析两组基因型及等位基因的差异.结果 rs4570625G等位基因与PSA的发病增加有关(OR=1.37,P=0.049);女性患者的GG基因型和等位基因均显著高于对照组(P=0.025和P=0.035,OR=1.721,P=0.009).两组间rs4565946等位基因和基因型的差异无统计学意义.G-C单倍体的患者PSA的发病危险性增加(OR=1.89,P＜0.01).结论 TPH2基因多态性可能与PSA的发病相关.

abstractsObjective To investigate the association of two functional polymorphisms of tryptophan hydroxylase 2(THP2) gene,rs4570625 and rs4565946,with poststroke anxiety disorders.Methods Totally 112 poststroke anxiety patients and 246 non-anxious stroke controls were included and completed Hamilton Anxiety Rating Scale.DNA was extracted from blood and genotyped for the two polymorphisms of THP2 gene by polymorphism chain reaction.Results The G allele of rs4570625 was associated with the increased risk of poststroke anxiety.Both the GG genotype and G allele were observed to be significantly higher in female case than in control.No significant difference in genotype and allele firequencies of the rs4565946 was found among the groups.Patients with the G-C haplotype had significantly increased the risk of poststroke anxiety compared to controls.Conclusions Our findings suggest that these ftmctional polymorphisms in TPH2 gene may be involved in development of poststroke anxiety.