摘要目的 探讨原发性或隐源性癫痫儿童生态学执行功能特点及其影响因素.方法 对50名原发性或隐源性癫痫儿童和50名性别、年龄、受教育年限等与之匹配的正常儿童,进行执行功能行为评定量表(BRIEF)父母版问卷评定.结果 (1)原发性或隐源性癫痫儿童BRIEF量表总分及行为管理指数、元认知指数两个维度得分[分别为(55.12±10.49)分、(53.74±10.35)分、(56.60±10.99)分]均明显高于对照组[分别为(48.10±6.35)分、(47.18±5.84)分、(48.16±6.23)分],差异有统计学意义(P＜0.01).(2)多元逐步回归分析显示,发作类型、性别、年龄、癫痫发作控制与否四个临床特征与BRIEF显著相关(P＜0.05),未发现受教育程度、首发年龄、病程、家族史及服药等与BRIEF显著相关(P＞0.05).结论 原发性或隐源性癫痫儿童生态学执行功能存在缺陷,受发作类型、性别、年龄、癫痫发作控制与否的显著影响.

abstractsObjective To explore features and relevant factors about the ecological executive function of children with idiopathic or cryptogenic epilepsy.Methods 50 children with idiopathic or cryptogenic epilepsy against were compared with 50 normal ones of the same gender,age group and educational level.All the subjects'parents completed the Behavior Rating Inventory of Executive Function(BRIEF).Results The scores of children with idiopathic or cryptogenic epilepsy in global executive composite (GEC),behavioral regulation index (BRI) and metacognition index (M I) of BRIEF (respectively,55.12± 10.49,53.74 ± 10.35,56.60 ± 10.99) were significantly higher than those of the control group (respectively,48.10 ± 6.35,47.18± 5.84,48.16 ± 6.23) (P＜ 0.01).Multiple stepwise linear regression analysis showed that 4 clinical features namely seizure type,gender,age and epilepsy control were closely related to BRIEF while factors such as educational level,outbreak age,course of disease,family history and antiepileptic drugs were not relevant to BRIEF.Conclusion The ecological executive function of children with idiopathic or cryptogenic epilepsy faulty and is affected by seizure type,gender,age,epilepsy control.