摘要目的 探讨学龄期早期注意缺陷多动障碍儿童(ADHD)汉字语义加工的特征及其与行为问题的相关性.方法 7～8岁的ADHD儿童及正常儿童各20名,用事件相关电位技术(ERP)进行语义识别过程的检测,用Conners父母症状问卷量表评估儿童行为问题,对ERP结果与量表行为因子得分进行统计分析.结果 (1)ERP结果:ADHD汉字ERP-P200波幅(μV)明显低于正常组[相关(6.6±4.8) μV比(11.6±6.4) μV;不相关(6.7±3.7)μV比(10.8±5.0)μV];潜伏期(ms)明显延长[相关(240± 30) ms比(198±17)ms,不相关(232±26) ms比(194±16) ms,假字(233±26) ms比(197±15)ms],均差异有统计学意义(P＜0.05).ADHD三种汉字条件N400波幅与正常组相比仅呈降低趋势(P＞0.05),而潜伏期明显延长(P＜0.05).(2)量表结果:ADHD的品行、学习问题、冲动多动、多动指数的因子分明显升高.(3)相关性分析:ERP汉字相关P200波幅与量表品行、心身障碍、冲动-多动和多动指数均呈负相关(r=-0.51,-0.47,-0.45,-0.46,均P＜0.05),相关P200波潜伏期与心身障碍呈正相关(r=0.54,P=0.01).结论 学龄期早期ADHD儿童在语义识别早期已经存在加工障碍.P200可作为评估学龄早期ADHD语言认知的客观指标,并与品行、冲动等行为问题相关.

abstractsObjective To explore Chinese character semantic processing feature and the relationship with behavioral problems in early childhood with ADHD.Methods Twenty ADHD children and twenty normal children (7-8 years old) performed a Chinese character semantic judgment task through event related potential (ERP),meanwhile Conners parent rating scale (PSQ) was completed by parents to analyze behavior problems in children.The relationship between behavioral problems and ERPs was analyzed.Results (1) ADHD group showed smaller amplitudes of P200 compared to the normal group (related (6.6±4.8) μV vs (11.6±6.4) μV;unrelated (6.7±3.7) μN vs (10.8±5.0) μV),and longer latency (related(240±30) ms vs (198±17)ms;the unrelated (232±26)ms vs (194±16)ms;psudoword (233±26)ms vs (197±15)ms),all P＜0.05).The amplitudes of N400 wave only showed a decreasing trend in ADHD group(P＞0.05),while the latency of N400 was significantly longer than that in normal children in three conditions(P＜0.05).(2) Four subscale scores of CPSQ(conduct problem,learning problem,hyperactivity-impulsion and hyperactivity index) were significantly higher in ADHD children compared with normal group.(3)The amplitudes of P200 in related condition had negative correlation with the scores of CPSQ subscale (conduct problem,psychoso matic disorder,hyperactivity-impulsion and hyperactivity index) (r=-0.51,-0.47,-0.45,-0.46,all P＜0.05.The latency of P200 in related condition had positive correlation with psychosomatic disorder scores (r =0.54,P=0.01).Conclusion Early semantic recognition disorder exists in 7～ 8 years old ADHD children.P200 can be used as an objective index to evaluate early childhood ADHD's language cognition,and P200 is related to behavior problems (such as conduct problem,impulsions).