摘要目的 探讨精神分裂症和强迫症记忆监测的特点.方法 对符合DSM-5相应诊断标准的44例精神分裂症患者和42例强迫症患者以及51例正常健康对照进行情景记忆知晓感(FOK)的测验.结果 精神分裂症患者线索回忆和再认正确率[0.30(0.15,0.50),0.75(0.56,0.90)]均低于正常对照[0.70(0.50,0.85),0.95(0.85,1.00)]和强迫症患者[0.65(0.39,0.76),0.95(0.84,1.00)],差异具有统计学意义(均P<0.01).强迫症患者线索回忆的正确率低于正常对照,差异有统计学意义(P<0.05).在高估方面,三组[0.21(0.00,0.32),0.15(0.00,0.33),0.09(0.00,0.25)]均差异无统计学意义(P>0.05).在低估上,精神分裂症患者[0.12(0.00,0.36)]高于强迫症患者[0.00(0.00,0.20)]和正常对照[0.00(0.00,0.22)],差异有统计学意义(分别为P<0.05,P<0.01),强迫症患者和正常对照差异无统计学意义(P>0.05).精神分裂症患者的Hamann系数[0.19(-0.11,0.43)]低于强迫症患者[0.41(0.13,0.78)]和正常对照[0.56(0.14,1.00)],差异有统计学意义(P<0.01),强迫症患者和正常对照差异无统计学意义(P>0.05).精神分裂症患者(r=0.39,P<0.01)和正常对照(r=0.52,P<0.001)的回忆正确率和Hamann系数成正相关.结论 精神分裂症患者和强迫症患者的情景记忆均受损,但精神分裂症患者的记忆监测能力受损,强迫症患者完整.

abstractsObjective To compare the features of memory monitoring between schizophrenia and obsessive-compulsive disorder in patients. Methods 44 schizophrenia patients and 42 obsessive-compulsive disorder patients who met the DSM-V diagnosis and 51 healthy controls were assessed with feeling-of-knowing ( FOK) for episode memory test. Results Schizophrenia patients had significantly poorer cued recall and recognition performance (0.30(0.15,0.50),0.75(0.56,0.90)) compared with healthy controls(0.70(0.50, 0.85),0.95(0.85,1.00)) and obsessive-compulsive disorder patients(0.65(0.39,0.76),0.95(0.84,1.00)) (all P<0.001).There was significant difference between obsessive-compulsive disorder patients and healthy controls in cued recall performance(P<0.05).There was no difference among the three groups in overestimate index(0.21(0.00,0.32),0.15(0.00,0.33),0.09(0.00,0.25),all P>0.05).In underestimate index,schizo-phrenia patients'' values(0.12(0.00,0.36)) were significantly higher than that of healthy controls(0.00 (0.00,0.22)) and obsessive-compulsive disorder patients(0.00(0.00,0.20))( P<0.05, P<0.01),but there was no difference between obsessive-compulsive disorder patients and healthy controls(P>0.05).Schizophre-nia patients'' Hamann index(0.19(-0.11,0.43)) was significantly lower than that of healthy controls(0.56 (0.14,1.00)) and obsessive-compulsive disorder patients(0.41(0.13,0.78))(P<0.01),but there was no difference between obsessive-compulsive disorder patients and healthy controls(P>0.05).Cued recall perform-ance was positively correlated with Hamann index in patients with schizophrenia( r=0.39, P<0.01) and healthy controls( r=0.52, P<0.001). Conclusion Patients with schizophrenia and obsessive-compulsive disorder both have episode memory impairments,memory monitoring impairment is observed in schizophrenia patients,but not in obsessive-compulsive disorder patients.