摘要目的 探讨青少年吸烟成瘾者在Flanker任务下事件相关电位(event-related potentials, ERP)的错误正电位(error positivity,Pe)是否存在变化.方法 采用15名青少年吸烟成瘾者以及相匹配的15名不吸烟健康对照组的脑电图,比较Flanker任务下青少年吸烟成瘾者和不吸烟健康对照组的ERP.结果 青少年吸烟成瘾者 ERP 的 Pe 波幅[(3.575 ± 2.299)μV]相对于健康非吸烟者[(5.865±4.290)μV]明显降低(F=5.324,P=0.029),并且青少年吸烟成瘾组的Flanker任务反应时[(440.754±36.051)ms]明显高于对照组[(422.850±20.194)ms](F=0.620,P<0.05).Pearson相关性分析显示,青少年吸烟成瘾者的Pe波幅和吸烟指数(包年)显著相关(r=0.599,P=0.018).结论 青少年吸烟成瘾者存在错误监控能力方面的障碍.

abstractsObjective To investigate the change of the error positivity(Pe)of event-related poten-tial(ERP)under Flanker task in adolescents with smoking addiction. Method The signals of ERP during the Flanker task in fifteen adolescents with smoking addiction were compared with that of 15 non-smoking ad-olescents. Results The Pe amplitude in adolescents with smoking addiction((3.575±2.299)μV)was sig-nificantly lower than that of non-smokers((5.865 ± 4.290)μV)(F=5.324,P=0.029),and the reaction time of the Flanker task in smoking addiction adolescent group((440.754± 36.051)ms)was significantly higher than that in the control group((422.850±20.194)ms)(F=0.620,P<0.05).The Pe amplitude in ado-lescents with smoking addiction was positively correlated with smoking index(pack-years)(r=0.599,P=0.018). Conclusion The adolescents with smoking addiction may exit worse ability of error monitoring dur-ing the Flanker task.