摘要目的 通过对首发抽动障碍(tic disorders,TD)患儿Oddball任务行为学及事件相关电位(event-related potentials,ERP)的研究,探讨注意定向功能的变化.方法 选取TD患儿、正常儿童各30名,对全部被试进行Oddball任务检测,对行为学结果及P300的亚成分P3a、P3b进行分析.结果 TD患儿的击中数[49(48,50)次]低于正常儿童[50(49,50)次] (P<0. 05),P3a波幅的分组主效应(F=6. 047,P=0. 015)、分组×条件交互效应显著(F=4. 619,P=0. 034),TD患儿靶P3a波幅[(5. 91 ±4. 51)μV]显著低于正常对照儿童[(9. 57±5. 80)μV](P<0. 05).而P3a潜伏期、P3b波幅与潜伏期分组×条件交互效应均不显著(P>0. 05).结论 首发抽动障碍患儿对新奇刺激的注意定向可能存在损害.

abstractsObjective To explore the changes of attention cognitive function by studying Oddball task behavior and event-related potentials(ERPs) in children with first-episode tic disorder(TD). Methods Oddball task was tested in 30 children with TD and 30 normal children,and their behavioral data and P3a/P3b components of ERPs were analyzed. Results Children with TD had a lower hitting number (49(48, 50)) than control group (50(49,50),P<0. 05). The main effect of group ( F=6. 047,P=0. 015) and the interaction effect between group and condition (F=4. 619,P=0. 034) on the amplitude of P3a were signifi-cant(P<0. 05). The amplitude of P3a component ((5. 91±4. 51)μV ) in TD group were smaller than that in the control group((9. 57±5. 80)μV)(P<0. 05). However,there was no significant interaction effect be-tween group and condition on P3a latency,P3b amplitude and latency (P>0. 05). Conclusion Attentional orienting is impaired in children with TD.