摘要目的 研究轻型颅脑损伤( mild traumatic brain injury,mTBI)对功能脑网络参数的影响,分析mTBI患者脑网络小世界属性的变化.方法 收集上海交通大学医学院附属第九人民医院神经外科轻型颅脑损伤患者10例及年龄、性别相互匹配的健康对照组13例,采集所有受试者的静息态功能磁共振图像,构建功能网络,分析脑网络属性.结果 在所选择的稀疏度范围下颅脑损伤组与健康对照组均具有小世界属性.颅脑损伤患者的全局效率与健康对照组相比显著降低[( 0. 174 ± 0. 141)、(0. 184±0. 062), t=2. 417,P=0. 025],最短路径长度较健康对照组显著增加[( 0. 797 ± 0. 930)、(0. 734±0. 488),t=-2. 083,P=0. 048].结论 轻型颅脑损伤患者功能脑网络具有小世界属性,患者功能脑网络的参数发生改变.

abstractsObjective To analyze the effects of mild traumatic brain injury ( mTBI) on functional brain network parameters and to study the properties of small world of patients. Methods Ten patients with mild traumatic brain injury and 13 healthy controls matched by age and sex were collected from the Ninth People's Hospital Affiliated to Medical College of Shanghai Jiao Tong University. Resting functional magnetic resonance images of all subjects were collected. Functional networks were constructed and brain network properties were analyzed. Results The brain injury group and the healthy control group had small world at-tributes in the selected sparseness range. The global efficiency of patients with mTBI patients was significantly reduced compared to healthy control group (0. 174±0. 141 vs 0. 184±0. 062),t=2. 417,P=0. 025),and the shortest path length was increased compared to healthy control group (0. 797±0. 930 vs 0. 734±0. 488),t=-2. 083,P=0. 048). Conclusion The functional brain network of patients with mTBI patients has small world attributes,and the parameters of functional brain network of patients have changed.