摘要目的:探讨社交焦虑障碍(social anxiety disorder，SAD)患者的面孔与非面孔加工以及不同情绪效价下面孔加工的相关激活脑区。方法:通过关键词检索了PubMed、Medline、Sciencedirect、CNKI等数据库，得到符合要求的31项经同行评议的SAD患者情绪面孔研究，其中SAD患者面孔与非面孔加工元分析纳入13篇文献，包含被试481人、161个激活点。SAD患者不同情绪效价的面孔加工元分析纳入18篇文献，包含被试586人、331个激活点。基于Talairach空间下采用簇水平整体错误(Cluster-level family-wise error，FWE， P<0.05)方法分析。 结果:SAD患者的面孔加工激活了左侧杏仁核(x＝-18，y＝-8，z＝-12)，右侧杏仁核(x＝26，y ＝0，z＝-20)，内嗅皮层(Brodmann脑区28，x＝16，y＝-8，z＝-10)和内侧前额叶皮质(Brodmann脑区10，x＝2，y＝44，z＝-8)。并且，SAD患者在处理负性面孔时左侧杏仁核(x＝-26，y＝0，z＝-16)，右侧杏仁核(x＝26，y＝0，z＝-12)，左内侧苍白球(x＝-20，y＝-10，z＝-6)和右内侧苍白球(x＝20，y＝-10，z＝-6)有强烈激活，其中恐惧面孔激活双侧杏仁核(左：x＝-28，y＝0，z＝-16，右：x＝28，y＝-2，z＝-12)、愤怒面孔激活内侧苍白球(x＝20，y＝-8，z＝-6)。结论:SAD患者的面孔加工存在特定神经机制，双侧杏仁核、内嗅皮层和内侧前额叶皮质是面孔加工的关键脑区，杏仁核和内侧苍白球是负性情绪面孔加工的重要神经区域。

abstractsObjective:To explore the relevant brain regions of face/non-face processing, and face processing under different emotional valence in patients with social anxiety disorder(SAD).Methods:PubMed, Medline, ScienceDirect, CNKI and other databases were retrieved, and 31 peer-reviewed emotional face studies of SAD patients were obtained (facial and non-facial processing: 13 literatures, 481 subjects, 161 foci; face processing with different emotional titers: 18 literatures, 586 subjects, 331 foci). Cluster-level family-wise error (FWE, P<0.05) based coordinates of Talairach space was adopted. Results:Face processing in SAD patients activated the left amygdala (x=-18, y=-8, z=-12), the right amygdala (x=26, y=0, z=-20), the entorhinal cortex (Brodmann area 28, x=16, y=-8, z=-10) and the medial prefrontal cortex (Brodmann area 10, x=2, y=44, z=-8). In addition, when SAD patients processed negative faces, the left amygdala (x=-26, y=0, z=-16), the right amygdala (x=26, y=0, z=-12), the left medial globus pallidus (x=-20, y=-10, z=-6) and right medial globus pallidus (x=20, y=-10, z=-6) had strong activation, which fear faces activated bilateral amygdala (left: x=-28, y=0, z=-16, right: x=28, y=-2, z=-12) and angry faces activated the medial globus pallidus (x=20, y=-8, z=-6).Conclusion:There are specific neural mechanisms for face processing in patients with SAD.Bilateral amygdala, entorhinal cortex and medial prefrontal cortex are key brain regions for face processing.The amygdala and medial globus pallidus are important neural regions for face processing of negative emotions.