摘要阿尔茨海默病(Alzheimer's disease，AD)的主要表现为认知功能下降，造成这种下降的重要原因在于视觉和听觉的缺陷。来自视觉和听觉的刺激信息以不同的模式输入，导致个体处理这两种信息时存在时间差，正常衰老的个体能够很好地整合这些来自不同通道的信息并进行反应，但AD患者由于病理性衰老，认知功能受损导致不能很好地完成视听整合。已有一系列研究关注了AD患者这种视听整合障碍在行为上的表现与其背后的神经生理机制，指出这种视听整合障碍可能由颞上沟区域的病理变化、大脑连通性和激活模式的异常等因素导致，并为可能的干预和预防方式提供了新思路。现将从AD患者视听整合障碍的行为学表现和生理病理改变造成的影响进行综述，总结干预和预防方式，并对未来研究进行展望。

abstractsThe main manefestation of Alzheimer's disease (AD) is cognitive decline. An important reason for this decline lies in the defects of vision and hearing. Stimuli information from vision and hearing are transmitted in different modes, resulting in a time difference between the receiving and encoding of these different types of information. Normal aging individuals are well capable of integrating information from different sensory modalities and respond to it, whereas AD patients cannot integrate such visual and auditory information very well due to pathological aging and impaired audiovisual integration ability. A series of studies have investigated the impaired audiovisual integration in AD patients, focusing on their behavioral performance and the underlying neurophysiological mechanism. Their findings indicate that the impaired audiovisual integration in AD patients could be caused by pathological changes in the superior temporal sulcus, as well as anomaly in brain connectivity and brain activity pattern and so on, which provide insights into potential intervention and prevention methods. This paper reviews the physiological, pathological, and behavioral manifestations of impaired audiovisual integration in AD patients, summarizes some intervention and prevention methods, and provides prospect for future research.