摘要冻结步态是帕金森病(Parkinson disease，PD)常见的、高致残、情境性、治疗上具有挑战性的一种步态障碍，目前尚缺少明确有效的干预手段。近十年来，基于认知-运动双任务的运动训练被越来越多地用于PD患者冻结步态的干预治疗，并取得一定的临床效果。运动训练促进肌肉分泌肌因子的肌-脑串扰作用对PD冻结步态认知-运动康复至关重要，不同类型和负荷的认知-运动双任务对步态的影响存在差异，但具体训练类型和负荷及作用机制仍需要进一步阐明。本文就PD患者冻结步态认知-运动干扰效应中肌-脑串扰机制研究进展进行归纳概括，旨在为PD患者冻结步态临床认知-运动训练干预提供新的理论视角。

abstractsFreezing of gait is a common gait disorder in Parkinson disease (PD), which is highly disabling, situational and therapeutically challenging. At present, there is no clear and effective intervention method. In recent ten years, exercise training based on cognitive-motor dual tasks has been more and more used in the intervention treatment of freezing of gait of PD patients, and achieved certain clinical results. The muscle-brain crosstalk effect of exercise training promoting muscle secretory factors is crucial for freezing of gait rehabilitation of PD. There are differences in the effects of cognitive-motor dual tasks of different types and loads on gait, but the specific training types and loads and mechanism of action still need to be further elucidated. This paper focuses on the research progress of muscle-brain crosstalk mechanism in cognitive-motor interference effect of freezing of gait in PD patients, aiming to providing a new theoretical perspective for clinical cognitive-motor training intervention of freezing of gait in PD patients.