换一批摘要Tetrandrine, a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore, exhibits very broad pharmacological actions, including anti-tumor activity. The beneficial effects of tetrandrine on tumor cell cytotoxicity and radiosensitization, multidrug resistance, normal tissue radioprotection, and angiogenesis are most promising and deserve great attention. Tetrandrine has potential either as a tumoricidal agent or as an adjunct to chemotherapy and radiotherapy. To evaluate the potential clinical efficacy of tetrandrine for cancer therapy,more mechanism-based pharmacological, pharmacokinetic, and pharmacodynamic studies are required.
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关键词
tetrandrineapoptosisradiation-sensitizing agentsradiation protectionmultiple drug resistanceangiogenesis
分类号
R96（药理学）
发布时间
2007-07-26（万方平台首次上网日期，不代表论文的发表时间）
基金项目
Projected supported by the National Science Council（(91-2314-B-195-009)）
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