摘要Aim: To investigate the effects of allisartan, a new angiotensin Ⅱ type 1 (AT1) receptor antagonist, on blood pressure (BP) and end-organ damage (EOD) in hypertensive rats and dogs. Methods: First, a single dose of allisartan was given intragastricaUy to evaluate the BP reduction in spontaneously hyper-tensive rats (SHRs), two kidney-one clip (2K1C) renovascular hypertensive rats and dogs, and Beagle dogs with angiotensin Ⅱ-induced hypertension. Second, aUisartan was mixed in rat chow for long-term treatment. After 4 months of drug admin-istration, rats were instrumented to determine BP and baroreflex sensitivity (BRS). Observation of morphologic changes was used to estimate EOD. Third, the acute toxicity of allisartan was compared with that of losartan in mice. Results: BP was significantly decreased after intragastric administration of allisartan in SHRs, 2K1C rats, 2K1C dogs and with allisartan exhibited an improved BRS and organ protective effects. Mice who were administered allisartan experi-enced less acute toxicity than those treated with losartan.Conclusion: Auisartan is highly effective for BP reduction and organ protection with low toxicity.