Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

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作者 Teng-teng Li ^[1] Cheng Peng ^[2] Ji-qiu Wang ^[3] Zhi-jian Xu ^[2] Ming-bo Su ^[4] Jia Li ^[1] Wei-liang Zhu ^[2] Jing-ya Li ^[4] 学术成果认领

作者单位 State Key Laboratory of Drug Research,the National Drug Screening Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China ^[1] CAS Key Laboratory of Receptor Research;Drug Discovery and Design Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China ^[2] Schoolof Pharmacy,University of Chinese Academy of Sciences,Beijing 100049,China ^[3] State Key Laboratory of Drug Research,the National Drug Screening Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China ^[4]

关键词 DPP4 distal mutation enzymatic activity molecular dynamics simulation structure-function mechanism

栏目名称 Molecular and Cellular Pharmacology

发布时间 2022-10-09

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中国药理学报（英文版）

2022年43卷8期

2147-2155页

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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

中国药理学报（英文版）

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中国药理学报（英文版）

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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

中国药理学报（英文版）

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中国药理学报（英文版）

相关期刊

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