摘要Pattern recognition receptors are an essential part of the immune system,which detect pathogen-associated molecular patterns(PAMPs)and damage-associated molecular patterns(DAMPs)and help shape both innate and adaptive immune responses.When dsDNA is present,cyclic GMP-AMP Synthase(cGAS)produces a second messenger called cyclic GMP-AMP(cGAMP),which then triggers an adaptor protein called STING,and eventually activates the expression of type Ⅰ interferon(IFN)and pro-inflammatory cytokines in immune cells.The cGAS-STING signaling pathway has been receiving a lot of attention lately as a key immune-surveillance mediator.In this review,we summarize the present circumstances of the cGAS-STING signaling pathway in viral infections and inflammatory diseases,as well as autoimmune diseases.Modulation of the cGAS-STING signaling pathway provides potential strategies for treating viral infections,inflammatory diseases,and autoimmune diseases.