摘要β-arrestin2,a pivotal protein within the arrestin family,is localized in the cytoplasm,plasma membrane and nucleus,and regulates G protein-coupled receptors(GPCRs)signaling.Recent evidence shows that β-arrestin2 plays a dual role in regulating GPCRs by mediating desensitization and internalization,and by acting as a scaffold for the internalization,kinase activation,and the modulation of various signaling pathways,including NF-κB,MAPK,and TGF-β pathways of non-GPCRs.Earlier studies have identified that β-arrestin2 is essential in regulating immune cell infiltration,inflammatory factor release,and inflammatory cell proliferation.Evidently,β-arrestin2 is integral to the pathological mechanisms of inflammatory immune diseases,such as inflammatory bowel disease,sepsis,asthma,rheumatoid arthritis,organ fibrosis,and tumors.Research on the modulation of β-arrestin2 offers a promising strategy for the development of pharmaceuticals targeting inflammatory immune diseases.This review meticulously describes the roles of β-arrestin2 in cells associated with inflammatory immune responses and explores its pathological relevance in various inflammatory immune diseases.