空气燃烧排放提取物小鼠致肺癌作用

Lung tumorigenicity of airborne complex mixtures emitted from combustion effluents

二维码有效期 120s

摘要目的评价6种具有致突变作用的空气燃烧排放提取物的致肺癌作用.方法用CD-1小鼠肺瘤生物测试方法,在小鼠断奶前处理受试物3次,6个月后观察肿瘤的发生率和病理组织学改变.并以苯并芘作为阳性对照.结果 6种具有突变作用的空气燃烧排放提取物均具有致肺癌作用,并呈剂量-效应关系,另外发现其致肺癌作用与其中是否含二氯甲烷无关.

作者唐莉莉 ^[1] 唐萌 ^[2] 贺霞 ^[3] William F BUSBY Jr ^[4] 王加生 ^[5] 学术成果认领

作者单位 Department of Environmental Toxicology and the Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409, USA;江南大学,江苏,无锡,214036 ^[1] Department of Environmental Toxicology and the Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409, USA;东南大学,江苏,南京,210009 ^[2] Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA ^[3] Massachusetts Institute of Technology,Cambridge, MA 02139, USA ^[4] Department of Environmental Toxicology and the Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409, USA ^[5]

关键词空气燃烧排放物苯并芘类多环碳氢化合物,芳香族致癌性试验肺肿瘤 airborne complex mixture benzopyrenes polycyclic hydrocarbons,aromatic carcinogenecity tests lung neoplasms

主题词肺肿瘤(Lung Neoplasms)空气(Air)小鼠(Mice)苯并芘类(Benzopyrenes)多环化合物(Polycyclic Compounds)

分类号 R994.6

栏目名称 中国旅美毒理学家协会论文汇编

发布时间 2004-06-04

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交