摘要目的 探讨缄性成纤维细胞生长因子(bFGF)和CD105在胃癌组织中的表达及其生物学行为.方法 采用免疫组化检测60例胃癌组织及20例正常胃组织中bFGF与微血管密度(MVt))的表达和胃癌细胞增殖指数(SPF).用TUNEL原位凋亡法检测胃癌组织中胃癌细胞凋亡,计算凋亡率(AR).结果 胃癌组织中bFGF蛋白表达、MVD、SPF明显高于正常胃组织,而AR低于正常胃组织.bFGF、MVD和SPF呈正相关(r=0.48、0.51、0.46,P<0.05).bFGF和MVD与AR呈负相关(r=-0.44、-0.47、0.43,P<0.05).结论 bFGF可能通过上调MVD的表达,从而促进胃癌细胞增殖,抑制胃癌细胞凋亡.

abstractsObjective To investigate basic fibroblast grow th factor (bFGF) and CDI05 in gastric carcinoma and its biological be-havior. Methods bFGF, microvessel density (MVD) and stomach cancer cell S phase fraction (SPF) in 60 samples from stomach cancer patients and 20 samples from normal stomach were detected with immunohistochemistry.. Apoptosis in stomach cancer was determined with TUNEL and apoptosis rate (AR) was calculated. Results bFGF protein expression, MVD and SPF in stomach cancer patients were obvi-ously higher than that normal health controls, but AR were lower, bFGF and MVD showed positive relationship with SPF, and negative with AR. Conclusion bFGF possibly increased the MVD state, promoted stomach cancer cell multiplication, suppressed stomach cancer cell ap-optosis.