摘要目的 观察急性脑梗死患者血清脂联素与CRP和Hcy的相关性,进一步探讨其发病机制.方法 测定80例急性脑梗死患者(脑梗死组)和80例健康者(对照组)的血清脂联素、hs-CRP、Hcy、血脂、FPG和血压等指标.结果 急性脑梗死患者的血清hs-CRP、Hcy、TG和收缩压显著高于对照组(P＜0.05),血清脂联素显著低于对照组(P＜0.05).脂联素与Hcy(r=-0.453)、hs-CRP(r=-0.397)、TG(r=-0.321)、FPG(r=-0.318)和收缩压(r=-0.288)呈负相关(P＜0.05).结论 脂联素与Hcy和hs-CRP、糖脂代谢和血压相互影响,共同参与急性脑梗死发生发展的病理生理过程.

abstractsObjective To investigate the correlation between adiponectin, CRP and homocysteine (Hcy) and evaluate its mechanism in acute cerebral infarction. Methods Serum adiponectin, hs-CRP,Hcy, blood lipid, FPG and blood pressure were measured in eighty patients with acute cerebral infarction ( cerebral infarction group) and eighty healthy persons ( control group). Results In cerebral infarction group, serum hs-CRP, Hcy, TG , and systolic pressure were significantly higher than in control group ( P ＜0. 05) , while serum adiponectin were significantly lower than in control group ( P ＜0. 05). Serum adiponectin levels were negatively correlated with Hcy( r = -0. 453) , hs-CRP ( r = -0. 397) ,TG( r = -0. 321) , FPG( r = -0. 318) and systolic pressure ( r = -0. 288). Conclusion There is correlation between adiponectin, Hcy, hs-CRP, glucose and lipid metabolism and blood pressure, which plays a role in occurrenc and development of acute cerebral infarction.