摘要目的 探讨结直肠癌患者行根治术后给予5 -FU/LV和FOLFOX4两种不同辅助化疗方案的疗效以及安全性.方法 回顾性分析本院2005年12月至2007年5月123例结直肠癌根治术后患者,其中术后接受5 -FU/LV化疗方案68例,接受FOLFOX4方案55例,比较两组患者生存率,化疗不良反应.结果 5-FU/LV和FOLFOX4组患者术后3年生存率分别为77.3％和80.0％,两组比较差异无统计学意义(x2=1.26,P ＝0.28).两组患者术后辅助化疗的不良反应主要为粒细胞下降、胃肠道不良反应、脱发等,两组不良反应发生率比较差异无统计学意义(P＞0.05).结论 5-FU/LV和FOLFOX4做为结直肠癌患者术后辅助化疗方案疗效确切,毒副反应均可耐受.

abstractsObjective To evaluate the efficacy and safety of two different adjuvant chemotherapy regimens of 5-FU/LV and FOLFOX4 in patients who suffered from colorectal cancer after having radical surgery.Methods By 123 patient who had colorectal cancer and received radical surgery from December 2005,to May 2007 were enrolled in this using retrospective analysis.68 cases received 5 FU/LV chemotherapy regimens and 35 cases received FOLFOX4 chemotherapy regimens.The results of survival rate and side effects were compared between the two groups.Results The survival rates within 3 years of 5-FU/LV and FOLFOX were 77.3％ and 80％ respectively.There was no significant differences between two chemotherapy regimens ( x2 =1.26,P =0.28).The main side effects included anorexia,nausca/vomiting,alopecia and et al.However there was no significant difference in adverse reactions of two groups ( P ＞0.05 ).Conclusions 5-FU/LV and FOLFOX4 were effective and safe chemotherapy regiments for patients with colorectal cancer after having radical surgery,and the side effects were acceptable in these two groups.