摘要目的 观察超脉冲CO2激光联合胶原贴敷料治疗原发性皮肤淀粉样变临床疗效及安全性.方法 将68例原发性皮肤淀粉样变病患者按治疗方法不同分成两组,对照组(33例)给予阿维A胶囊口服,同时外用复方氟米松软膏封包治疗;观察组(35例)采用超脉冲CO2激光联合胶原贴敷料外敷治疗,观察两组患者的治疗效果和不良反应.结果 观察组治疗后疾病积分显著低于对照组(t =3.12,P＜0.05);观察组有效率[88.6％ (31/35)]高于对照组[51.5％ (17/33),x2=11.23,P ＜0.01],观察组治愈时间[(5.38±1.81)d]明显短于对照组[(10.75 ±2.06)d,t=11.39,P＜0.01];观察组无一例复发,与对照组比较差异有统计学意义(x2=4.90,P ＜0.05).结论 超脉冲CO2激光联合胶原贴敷料治疗原发性皮肤淀粉样变疗效显著,具有创面愈合快、不良反应少等优势,值得临床推广应用.

abstractsObjective To investigate the clinical efficacy and safety of ultra pulse CO2 laser combined with collagen dressing in treatment of cutaneous amyloidosis.Methods A total of 68 cases of primary cutaneous amyloidosis patients according to the different treatment methods was divided into two groups:the control group (n =33 cases) that was given acitretin capsules oral and topical compound flumetasone ointment packet treatment,and observation group (n =35 cases) with ultra pulse CO2 laser combined with collagen dressing external treatment.Two groups were observed in patients with curative effect and adverse reaction.Results Disease of integral observation group after treatment was significantly lower than the control group(t =3.12,P ＜0.05).The observation group had the efficiency of [88.6％ (31/35)] that was significantly higher than that of control group[17/33(51.5％),x2 =11.23,P ＜.0.01].The observation group had significantly shorter healing time [(5.38 ± 1.81) d] compared to the control group [(10.75 ±2.06)d,t =11.39,P ＜ 0.01].The observation group did not have recurrence,which was significantly different from the control group (x2 =4.90,P ＜ 0.05).Conclusions Ultra pulse CO2 laser combined with collagen dressing in treatment of primary cutaneous amyloidosis is a kind of effective treatment methods with remarkable curative effect and less adverse reactions.It is worthy of clinical application.