摘要本文简要描述了乳腺癌化疗耐药与侵袭转移的相互作用和内在联系;并从乳腺癌上皮间充质转化(EMT)的形成和转归,乳腺癌干细胞的富集和功能分析了耐药和转移发生的共同途径;指出化学治疗在发挥治疗作用的同时可能通过改变肿瘤微环境产生消极作用;提示对肿瘤微环境的理解将有助于制订防止和逆转耐药和转移的研究策略.

abstractsThis review article briefly described the interaction and inner link between chemotherapy tolerance and metastasis of breast cancer.The common pathways of occurrence of drug resistance and metastasis were analyzed with formation and outcome of breast cancer epithelial-mesenchymal transition (EMT) and with enrichment and function of breast cancer stem cells.The chemotherapy which play positive role in clinical practice was pointed out that may cause negative effects by changing tumor microenvironment.Those evidences show that the theory on tumor microenvironment will help to formulate the research strategies for preventing and reversing resistance of breast cancer to drug and metastasis.