摘要目的 探讨血管紧张素转化酶基因I/D(ACE I/D)多态性与白癜风的关系.方法 检索PubMed、Cochrane Library、中国学术期刊全文数据库、维普数据库和万方数据库,按纳入、排除标准纳入研究,评价纳入研究质量,并采用Stata 12.0进行定量分析.结果 最终纳入9篇病例对照研究.Meta分析结果显示,总人群的ACE I/D中基因型(DD+ I) vs.DI(OR=0.759,95％ CI:O.643～0.896,P=0.001),(DD+ DI) vs.II(OR=1.523,95％ CI:1.153 ～2.011,P=0.003)与白癜风易感性之间有相关性.亚组分析显示,亚洲人中基因型D vs.I(OR=1.381,95％ CI:1.054～1.810,P=0.019);DD vs.II(OR=1.830,95％:1.110 ～ 3.017,P=0.018);(DD+ II) vs.DI(OR=0.814,95％CI:O.667 ～0.994,P=0.043);(DD+ ID) vs.II (OR=1.690,95％CI:1.147 ～2.489,P=0.008);与白癜风发生有关.阿拉伯人群基因型(DD+ II)vs.DI(OR=0.545,95％ CI:0.354 ～0.840,P=0.006)与白癜风发生有关.通过Begg's检验判断发表偏倚,所有基因类型均不存在任何发表偏倚.结论 ACE I/D基因多态性可能与白癜风易感性有关.

abstractsObjective To investigate the relationship of angiotensin converting enzyme (ACE I/D) gene I/D polymorphism with vitiligo.Methods PubMed,the Cochrane Library,China academic journal full-text database and VIP database and Wan fang database were searched according to the inclusion and exclusion criteria,and the quality of included studies was assessed.The data were quantitatively analyzed by Stata 12.0 software.Results Nine articles were included.Meta analysis results showed that the susceptibility of vitiligo difference was statistically significant in the total population of ACE I/D genotype (DD + II)vs.DI (OR=0.759,95％ CI:0.643 ～0.896,P=0.001),the (DD+DI) vs.II (OR=1.523,95％ CI:1.153 ～2.011,P =0.003).The genotype subgroup analysis showed the D vs.I (OR =1.381,95％ CI:1.054 ～1.810,P=0.019),DDvs.II (OR=1.830,95％ CI:1.110～3.017,P=0.018),(DD+ II) vs.DI (OR=0.814,95％ CI:0.667 ～0.994,P=0.043),and the (DD+ID) vs.II (OR=1.690,95％ CI:1.147 ～2.489,P =0.008) in Asian.The difference was statistically significantly related to vitiligo.Arab genotype (DD + II) vs.DI (OR =0.545,95％ CI:0.354 ～ 0.840,P =0.006) was associated with vitiligo occurrence.Begg's inspection publication bias analysis showed all genetic types did not exist any publication bias.Conclusions The ACE gene I/D polymorphism may be associated with vitiligo susceptibility.