摘要质子泵抑制剂的诞生是二十世纪消化系统疾病治疗史上的一座里程碑,但近年来,全国乃至欧美医学发达国家,从治疗性应用到预防性应用,临床使用原子泵抑制剂的科室愈来愈多,用药指征不断扩大,预防性不合理应用现象愈来愈严重.但目前国内外指南、专家共识涉及质子泵抑制剂预防性应用的内容比较零散,并多从疾病角度阐述,因此临床医师和药师急需一个全面、权威的预防性应用规范.自2012年起,扬州大学附属医院开始对门诊处方、医嘱中质子泵抑制剂应用合理性进行点评,2014年召开“全国质子泵抑制剂合理应用研讨会”,三次组织药学、消化病学、神经病学、重症医学、外科学等领域专家论证并起草“质子泵抑制剂预防性应用指导意见”,在作为医院内部规定执行三年后,结合最新国内外权威文献补充、完善后形成“质子泵抑制剂预防性应用专家共识”,用以指导临床医师合理应用,并作为药师处方、医嘱审核依据.

abstractsThe appearance of proton pump inhibitors (PPIs) is a milestone in the history of treatment of digestive system diseases in the 20th century.In recent years,PPIs were used from treatment to prevention in more and more clinical departments not only in China,but also in European and American countries,and constantly expanding its'indications.The phenomenon of unreasonable application of prevention is becoming more and more serious.However,domestic and foreign guidelines and expert consensus on prophylactic application of PPIs are relatively scattered and most of them are explained from the perspective of diseases.Therefore,clinicians and pharmacists are in urgent need of a comprehensive and authoritative standard for the preventive application of PPIs.Since 2012,Affiliated Hospital of Yangzhou University has begun to comment on the rationality of application of PPIs in out-patient prescriptions and medical orders.In 2014,the hospital held National Symposium on the Rational Application of Proton Pump Inhibitors.Experts in pharmacology,gastroenterology,neurology,critical care medicine,surgery and others demonstrated three times to draft the Guidelines on the Preventive Application of Proton Pump Inhibitors.It was implemented as an internal regulation in the hospital.Three years later,it was integrated with the latest domestic and foreign authoritative literature to compose the Expert Consensus on the Preventive Application of Proton Pump Inhibitors,which is used to guide clinicians and pharmacists.