摘要外伤、医源性损伤及神经系统病变等均可导致神经源性下尿路功能障碍(NLUTD).但在女性存在着一些较为特殊的病因,包括根治性子宫切除术、尿道中段悬吊术、盆腔脏器脱垂修复术、Fowler综合征、间质性膀胱炎等.由于NLUTD的复杂性、特殊性及难治性,使得一部分患者在经历过传统的行为训练、口服药物及手术治疗后难以达到满意的效果甚至发生疾病进展和恶化.在临床治疗上,越来越多的证据表明骶神经电调控(SNM)在治疗女性NLUTD中的优势.建立在现有文献报道的基础上,本文将对女性NLUTD的发生机制及SNM在该疾病中的应用进行回顾与总结.

abstractsTrauma,iatrogenic injury,and neurological disorders can lead to neurogenic lower urinary tract dysfunction (NLUTD).However,there are some special causes in women,including radical hysterectomy,mid-urethral suspension,pelvic organ prolapse repair,Fowler syndrome,interstitial cystitis etc.Traditional behavioral therapy,drug treatment and surgeries may work less well in patients with NLUTD and may even lead to progression and deterioration of the diseases.A review of current literatures revealed that there is an increasing evidence on the application of sacral neuromodulation (SNM) in the treatment of NLUTD in female.This review will provide a summary of the known mechanisms of female NLUTD and the effectiveness of SNM.