摘要目的:观察比较肺结核患者规律治疗3个月较治疗前肺功能的变化。方法:连续选取2018年4月至2019年6月在本院接受规律抗结核治疗的肺结核患者500例。观察患者治疗前、治疗3个月的肺功能状态，比较两次肺通气功能、肺容积、弥散功能的结果，具体指标包括用力肺活量(FVC)、第1秒最大呼气量(FEV 1)、第1秒最大呼气量/用力肺活量(FEV 1/FVC)、肺总量(TLC)、残气量(RV)和一氧化碳弥散量(D LCO)6项指标值的变化情况。 结果:排除失访病例216例、肺功能不符合质控标准者32例，最终纳入252例肺结核患者的资料。在治疗前和治疗3个月，肺功能6项指标结果中异常者分别为204例(80.95%)和193例(76.59%)，两个时期结果的差异无统计学意义( P>0.05)。其中以肺通气功能异常最为常见，且以阻塞性肺通气功能障碍为主。治疗3个月肺通气功能、肺容积正常者的比例较治疗前升高且差异有统计学意义( P<0.05)，而治疗前后弥散功能正常者的比例差异无统计学意义( P>0.05)。治疗3个月FVC、FEV 1、TLC、D LCO的值较治疗前升高，差异有统计学意义( t＝－6.414、－6.754、－3.863、－3.311， P均<0.01)。 结论:肺结核患者多数有肺功能损伤。肺结核患者治疗3个月肺通气功能、肺容积的正常率及FVC、FEV 1、TLC、D LCO的值较治疗前改善明显。

abstractsObjective:To observe and compare the changes of pulmonary function in patients with pulmonary tuberculosis regular treatment for 3 months.Methods:From April 2018 to June 2019, 500 tuberculosis patients who received regular anti tuberculosis treatment in our hospital were selected.The pulmonary function of patients with pulmonary tuberculosis was measured before treatment and at the end of three months; the results of pulmonary ventilation function, lung volume, diffusing capacity, and the value of forced vital capacity (FVC), maximum expiratory volume in 1 second (FEV 1), maximum expiratory volume in 1 second/forced vital capacity (FEV 1/FVC), total lung volume (TLC), residual volume (RV), carbon monoxide diffusing capacity (D LCO) were compared. Results:252 patients with pulmonary tuberculosis were included. Before treatment and at the end of three months, the abnormal pulmonary function results were 204 cases (80.95%) and 193 cases (76.59%), respectively, and the difference was not statistically significant ( P>0.05). Among them, abnormal pulmonary ventilation function is the most common, especially with obstructive, followed by abnormal diffusing capacity. At the end of three months, the proportions of patients with normal pulmonary ventilation function and normal lung volume were higher than that before treatment ( P<0.05), but there was no significant difference in the proportion of normal diffusing capacity before and after treatment ( P>0.05). The values of FVC, FEV 1, TLC and D LCO at the end of three months were higher than those before treatment, and the difference was statistically significant ( t=-6.414, -6.754, -3.863, -3.311, all P<0.01). Conclusions:Most patients with pulmonary tuberculosis have abnormal pulmonary function. At the end of the three months treatment, the normal rates of the pulmonary ventilation function and lung volume as well as the values of FVC, FEV 1, TLC and D LCO in patients with pulmonary tuberculosis were significantly improved compared with those before treatment.